This is highly multidisciplinary yand interdisciplinary area of research. Biology and its applications to medicine is characterised by enormous complexity. Complexity in the number of components involved, the number of interactions that occur and the complexity of those interactions. It is clear to that biological systems do not adhere to the science disciplines –instead operate in biochemical and biophysical world.
Our research focuses on integrating the physical, chemical and biological processes defining biological systems. This is relevant to understanding diseases such as osteoarthritis, tendonopathy, colorectal cancer, and acute kidney injury. Primarily this integration is done through developing computational and mathematical models of these systems. However all projects involve close collaboration with experimental biologists and clinicians.
Examples of recent publications
- Young, S.R., B. Gardiner, A. Mehdizadeh, J. Rubenson, B. Umberger, D.W. Smith, Adaptive remodeling of Achilles tendon: A multi-scale computational model, PLoS Computational Biology, 12(9): e1005106, 2016.
- Kar, S., D.W. Smith, B.S. Gardiner, Y. Li, Y. Wang, A.J. Grodzinsky, Modeling IL-1 induced degradation of articular cartilage, Archives of Biochemistry and Biophysics, 594: 37–53, 2016.
- Gardiner, B.S., F.G. Woodhouse, T.F. Besier, A.J. Grodzinsky, D.G. Lloyd, L. Zhang, D.W. Smith, Predicting knee osteoarthritis, Annals of Biomedical Engineering, 44 (1): 222-233, 2016.
- Gardiner, B.S., K.L. Wong, G.R. Joldes, A.J. Rich, C.W. Tan, A.W. Burgess, D.W. Smith, Discrete element framework for modelling extracellular matrix, deformable cells and subcellular components, PLoS Computational Biology, 11(10): e1004544, 2015.
- Woodhouse, F.G., B.S. Gardiner, D.W. Smith, Short-term consolidation of articular cartilage in the long-term context of osteoarthritis, Journal of Theoretical Biology, 368: 102-112, 2015.